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Slamf7-mAb
- Development stage
- Preclinical
- Lead developer
- Bristol Myers Squibb
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
Slamf7-mAb is an antibody-based immunotherapeutic designed to target the evolutionary conserved SLAM family member 7 (SLAMF7) immune receptor. Developed in a syngeneic mouse model, this monoclonal antibody aims to treat malignant hematological diseases, including multiple myeloma. Its mechanism involves binding to SLAMF7 on target cells, which then triggers antigen-specific antibody-dependent cellular cytotoxicity (ADCC) through the interaction of its Fc region with Fcγ receptor IV on immune effector cells. Preclinical studies have shown Slamf7-mAb to exert antitumor effects against SLAMF7-expressing targets and enhanced antimyeloma activity in allogeneic transplant settings.
02
Targets
SLAMF7 (Signaling lymphocytic activation molecule family member 7)FcγRIIIa (Low affinity immunoglobulin gamma Fc region receptor III-A)
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