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SLC15A4 inhibitor (BridGene Biosciences)
- Development stage
- Preclinical
- Lead developer
- BridGene Biosciences
- Modality
- Small Molecules
01
Overview
BridGene Biosciences is developing a small molecule inhibitor targeting SLC15A4 for the treatment of autoimmune diseases, including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). SLC15A4 is a lysosomal solute carrier protein that plays a critical role in Toll-like receptor (TLR) 7, 8, and 9 signaling and is essential for type I interferon production in immune cells, such as plasmacytoid dendritic cells. By inhibiting SLC15A4, the drug aims to modulate immune function and suppress the overactive inflammatory responses characteristic of these autoimmune conditions. The program is currently in the lead optimization phase of preclinical development.
- Other names
- SLC15A4 inhibitorSLC-15A4 inhibitorSLC 15A4 inhibitor
02
Targets
SLC15A4 (Solute carrier family 15 member 4)
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