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SLITone Dermatophagoides mix
- Development stage
- Phase 3
- Lead developer
- ALK Abelló
- Modality
- Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Sublingual
01
Overview
SLITone Dermatophagoides mix is a sublingual immunotherapy (SLIT) product developed by ALK-Abelló for the treatment of house dust mite (HDM) allergic rhinitis and asthma. It consists of a standardized extract of the house dust mites *Dermatophagoides pteronyssinus* and *Dermatophagoides farinae*. The therapy works by exposing the patient to controlled amounts of these allergens sublingually, which induces peripheral T-cell tolerance and shifts the immune response from a pro-allergic Th2 profile toward a Th1 and regulatory T-cell (Treg) profile. This modulation reduces the production of allergen-specific IgE and increases protective IgG4 antibodies, thereby decreasing allergic inflammation and symptoms upon natural exposure to house dust mites.
- Brand names
- SLITonePangramin SLIT HDM-mix
- Other names
- SLITone Dermatophagoides mixHouse dust mite allergen extractDermatophagoides pteronyssinus and Dermatophagoides farinae allergen extract
02
Targets
Der f (Dermatophagoides farinae allergens)
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