small humanin-like peptide 2

Small humanin-like peptide 2 is a **mitochondrial-derived 26-amino-acid peptide biologic** encoded within the mitochondrial **MT-RNR2** locus and studied as an experimental research peptide rather than an approved therapeutic product. Preclinical studies describe SHLP2 as a **CXCR7 agonist** with cytoprotective, anti-apoptotic, and metabolic regulatory activity, including improvement of mitochondrial respiration and biogenesis, reduction of reactive oxygen species, insulin-sensitizing effects, suppression of food intake, promotion of thermogenesis, and protection in models of diet-induced obesity and metabolic dysfunction. It has been explored in research settings for potential relevance to **obesity, type 2 diabetes, age-related macular degeneration, Parkinson's disease, and other mitochondrial dysfunction-related disorders**, but there is no clear evidence of branded clinical development by a specific biopharmaceutical company.

Other names

small humanin-like peptide 2SHLP2SHLP-2SHLP 2