Drug intelligence / Profile preview

small interfering RNA targeting NOD2

Development stage
Preclinical
Modality
Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
Administration
In Vitro Transfection, Intrarenal, Intratumoral, Intranasal, Topical, Electroporation, Endoscopic Injection, Pulmonary
01

Overview

A **small interfering RNA targeting NOD2** is an experimental RNA interference therapeutic concept designed to reduce expression of **nucleotide-binding oligomerization domain-containing protein 2** by promoting sequence-specific degradation of NOD2 mRNA. In the provided literature context, NOD2 knockdown suppressed IL-8 secretion and reduced proliferation and invasion in clear cell renal cell carcinoma cell models, supporting NOD2 silencing as a potential anticancer strategy. However, no uniquely identified clinical drug candidate, sponsor, branded product, or development program was established from the supplied evidence, so this term is best treated as a non-specific preclinical NOD2-directed siRNA concept rather than a clearly defined named asset.

Other names
NOD2 siRNANOD-2 siRNANOD 2 siRNAsiRNA targeting NOD2
02

Targets

NOD2 (Nucleotide-binding oligomerization domain-containing protein 2)

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