small interfering RNA targeting STARD13 + short hairpin RNA targeting STARD13

This combination refers to the use of small interfering RNA (siRNA) and short hairpin RNA (shRNA) to silence the expression of the STARD13 gene. STARD13 (also known as DLC2) is a RhoGAP protein that regulates the cytoskeleton and acts as a putative tumor suppressor. In the context of BRCA2-mutant breast cancer, STARD13 has been identified as a genetic modifier. Research indicates that STARD13 knockdown influences the Hippo pathway by regulating LATS2 activity. In wild-type cells, STARD13 loss induces a compensatory increase in LATS2, whereas in BRCA2-mutant cells, this compensation fails, potentially increasing cancer risk or altering therapeutic response. These RNA interference tools are primarily used in preclinical research to elucidate the STARD13-LATS2-BRCA2 axis and evaluate its potential as a therapeutic target or biomarker for hereditary breast cancer penetrance.

Other names

siRNA targeting STARD13 + shRNA targeting STARD13STARD13 knockdown RNAiSTARD-13 knockdown RNAiSTARD 13 knockdown RNAi