Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
SMARCAL1 shRNA
- Development stage
- Preclinical
- Lead developer
- Duke University
- Modality
- Viral-delivered RNAi → In Vivo RNAi → Gene Silencing → Gene Therapies, RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Parenteral
01
Overview
SMARCAL1 shRNA is a gene-silencing therapeutic candidate that utilizes short hairpin RNA to deplete SMARCAL1, an annealing helicase involved in replication fork reversal and DNA damage repair. In Alternative Lengthening of Telomeres (ALT+) high-grade gliomas, SMARCAL1 depletion induces replication catastrophe, increases DNA double-strand breaks, and enhances inflammatory signaling. Research conducted at Duke University indicates that SMARCAL1 inhibition synergizes with Topoisomerase I (TOP1) inhibitors, potentially overcoming resistance and boosting anti-tumor immunity in this specific glioma subtype.
- Other names
- SMARCAL1 short hairpin RNASMARCAL-1 short hairpin RNASMARCAL 1 short hairpin RNA
Beyond the preview
Go deeper on SMARCAL1 shRNA.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on SMARCAL1 shRNA.