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SMI-16a
- Development stage
- Preclinical
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
- Administration
- In Vitro (research Use Only; No Clinical Route Established)
01
Overview
SMI-16a is a potent and selective small molecule inhibitor of the proto-oncogene serine/threonine-protein kinases Pim-1 and Pim-2. It is a thiazolidinedione derivative that acts as an ATP-competitive inhibitor with IC50 values of approximately 150 nM for Pim1 and 20 nM for Pim2. These kinases are implicated in cell survival, proliferation, and drug resistance in various cancers—particularly hematological malignancies such as multiple myeloma. By inhibiting these kinases, SMI-16a disrupts oncogenic signaling pathways involved in tumor growth and survival. Preclinical studies have focused on its anti-cancer properties[1][3][4][5][8].
- Other names
- SMI-16aSMI16aSMI 16aPIM1/2 Kinase Inhibitor VIPim1/2 Inhibitor IVEVT-283642EVT283642EVT 283642
02
Targets
PIM1 (Proviral integration site for moloney murine leukemia virus kinase 1)PIM2 (Proto-oncogene serine/threonine-protein kinase Pim2)
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