Drug intelligence / Profile preview

SMO M.R Narco

Development stage
Preclinical
Lead developer
Debregeas et Associés Pharma
Modality
Small Molecules
Administration
Oral
01

Overview

SMO M.R Narco is a modified-release formulation of sodium oxybate (the sodium salt of gamma-hydroxybutyrate, GHB) being developed by Debregeas & Associés Pharma (D&A Pharma) for the treatment of narcolepsy. Sodium oxybate acts as an agonist at both the GHB receptor and the GABA-B receptor. In narcolepsy, it is used to improve sleep architecture and reduce symptoms such as cataplexy and excessive daytime sleepiness. The modified-release formulation is designed to optimize the pharmacokinetic profile of the drug, potentially allowing for a more convenient dosing regimen compared to immediate-release versions. It is currently in the preclinical stage of development.

Other names
sodium oxybate modified releasesodium oxybate MRsodium oxybate
02

Targets

GABA-B (Gamma-aminobutyric acid receptor type B)Gamma-hydroxybutyrate receptor

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