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SMP-ADeC

Development stage: Preclinical
Lead developer: Chengdu SciMount Pharmatech
Modality: PROTACs (E3 ligase recruitment) → Targeted Protein Degraders (TPDs) → Small Molecules, Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Bivalent/Multivalent Binders → Multivalent & Scaffold-Based Small Molecules → Small Molecules
Administration: Intravenous

Overview

SMP-ADeC is a preclinical antibody-drug conjugate (ADC) candidate developed by Chengdu SciMount Pharmatech (Xiling Lab) for the treatment of solid tumors. It utilizes an Antibody-PROTAC/DAC (Degrader-Antibody Conjugate) platform, which conjugates a monoclonal antibody to a PROTAC (Proteolysis-Targeting Chimera) payload. This modality is designed to achieve targeted protein degradation by delivering the degrader specifically to cells expressing the antibody's target antigen. As of the current pipeline status, the specific antibody target and the protein targeted for degradation have not been disclosed.

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