SMTP-44D

SMTP-44D is a small molecule derived from the fungus Stachybotrys microspora, belonging to the triprenyl phenol family. It acts as a **soluble epoxide hydrolase (sEH) inhibitor** and displays robust **antioxidant and anti-inflammatory properties**. Its mechanisms involve the inhibition of sEH, which increases beneficial epoxyeicosatrienoic acids (EETs) and decreases pro-inflammatory dihydroxyeicosatrienoic acids (DHETs), reducing oxidative stress, inflammation, and apoptosis. SMTP-44D also interferes with the receptor for advanced glycation end products (**RAGE**) pathway by blocking the interaction of advanced glycation end products (**AGEs**) with RAGE, contributing to neuroprotection in diabetic neuropathy and reduction of atherosclerotic plaque formation via suppression of **Cdk5-CD36**-mediated oxidized LDL uptake in macrophages. It is currently being investigated preclinically for conditions such as diabetic neuropathy and atherosclerosis[1][2][3][4].

Other names

Stachybotrys microspora triprenyl phenol-44D