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Smurf1 inhibitor
- Development stage
- Preclinical
- Lead developer
- Interprotein
- Modality
- Small Molecules
- Administration
- Oral, Intravitreal
01
Overview
Smurf1 inhibitor is a small molecule therapeutic candidate being developed by Interprotein for the treatment of cardiovascular diseases, specifically pulmonary arterial hypertension (PAH). The drug functions by inhibiting SMAD specific E3 ubiquitin protein ligase 1 (Smurf1), an enzyme that mediates the degradation of bone morphogenetic protein (BMP) signaling components, including SMAD1/5 and BMP type II receptors. In PAH, the loss of BMP signaling leads to pathological vascular remodeling; by blocking Smurf1-mediated degradation, this inhibitor aims to restore BMP pathway activity and ameliorate disease progression. The program is currently in the preclinical hit validation stage.
- Other names
- Smurf1 inhibitorSmurf-1 inhibitorSmurf 1 inhibitor
02
Targets
SMURF1 (SMAD-specific E3 ubiquitin-protein ligase 1)
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