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SN 31721
- Development stage
- Preclinical
- Lead developer
- The University of Auckland
- Modality
- Small Molecules
- Administration
- Oral, Intraperitoneal
01
Overview
SN 31721 is a small molecule morpholide-analog of *N*-(*o*-carboxybenzoyl)glutamic acid imide (CGI), which is an active hydrolysis metabolite of thalidomide. Developed by researchers at the University of Auckland, SN 31721 was designed to improve upon the potency and stability of CGI. It acts as an angiogenesis inhibitor, demonstrating significantly higher potency than CGI in inhibiting endothelial cell tube formation. Additionally, it inhibits the production of Interleukin-6 (IL-6), a key survival factor in the bone marrow microenvironment for multiple myeloma cells. In preclinical murine models, SN 31721 showed favorable stability at low pH and was well-tolerated at high doses, although it exhibited faster clearance compared to lenalidomide.
- Other names
- morpholide-analog of N-(o-carboxybenzoyl)glutamic acid imide
02
Targets
IL-6 (Interleukin 6)
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