SN3-L6

SN3-L6 is a synthetic dimeric derivative of the alkaloid securinine, developed as a differentiation-induction agent for the treatment of various forms of leukemia. It is characterized by its unique ability to induce the transdifferentiation of acute promyelocytic leukemia (APL) cells into morphologically and immunologically normal megakaryocytes and functional platelets. SN3-L6 also induces transdifferentiation in acute myeloid leukemia (AML) and chronic myelogenous leukemia (CML) cells, although it exhibits selectivity by targeting immature leukemia cells while sparing mature granulocytes. In CML K562 cells, the compound induces transdifferentiation into apoptotic megakaryocytes without platelet formation. This selective differentiation-induction activity suggests potential applications in differentiation therapy strategies for myeloid leukemias.

Other names

synthetic dimeric derivative of securinine