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SNAP-5114

Development stage: Unknown
Lead developer: Lundbeck
Modality: Small Molecules
Administration: Intracerebroventricular

Overview

SNAP-5114 is a selective small molecule inhibitor of the GABA transporters GAT-2 (SLC6A13) and GAT-3 (SLC6A11), with significantly lower affinity for the GAT-1 subtype. Developed by Synaptic Pharmaceutical Corporation, it is widely used as a pharmacological tool in neuroscience research to study the regulation of extracellular GABA levels and the role of astrocytic GABA transport in synaptic transmission. By blocking the reuptake of GABA into astrocytes, SNAP-5114 can modulate tonic inhibition and network excitability. It has been particularly useful in experimental models of epilepsy, such as temporal lobe and absence epilepsy, to investigate how glial cells contribute to seizure generation and to probe the mechanisms of antiepileptic drugs like levetiracetam.

Other names: 1-[2-[tris(4-methoxyphenyl)methoxy]ethyl]-3-piperidinecarboxylic acid(S)-1-[2-[tris(4-methoxyphenyl)methoxy]ethyl]-3-piperidinecarboxylic acid

Targets

GAT-3 (Sodium- and chloride-dependent GABA transporter 3)GAT2 (Sodium- and chloride-dependent GABA transporter 2)

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