SNC80

**SNC80** is a selective, non-peptide agonist of the δ-opioid receptor with high potency (Ki = 0.18 nM, IC50 = 2.73 nM), exhibiting over 2,000-fold selectivity against the μ-opioid receptor[2][3][4][9][10]. SNC80 activates both δ-opioid receptors and μ–δ opioid receptor heteromers[1][7]. It was developed as a research tool to study opioid receptor pharmacology, and displays analgesic, antidepressant, and anxiolytic effects in animal models, though its potential as a drug is limited by dose-related convulsions[1][4][5]. SNC80 is notable as the first non-peptide selective agonist for the δ-opioid receptor, discovered in 1994.

Brand names

SNC80SNC-80SNC 80

Other names

SNC80SNC-80SNC 804-((R)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl)(3-methoxyphenyl)methyl)-N,N-diethylbenzamideMLS002153330MLS-002153330MLS 002153330CHEMBL1730890CHEMBL-1730890CHEMBL 1730890HMS2235P18HMS-2235P18HMS 2235P18SMR001230743SMR-001230743SMR 001230743