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SND-635 is a first-in-class small molecule inhibitor targeting the nuclear receptor subfamily 4 group A member 1 (NR4A1), also known as Nur77. Developed by Floratek Pharma, the compound is derived from plant sources and is currently in the IND-enabling stage of development. SND-635 is being investigated for the treatment of solid tumors, specifically lung cancer and duodenal cancer. NR4A1 is a transcription factor that is frequently overexpressed in various malignancies, where it promotes cell survival, proliferation, and migration. By inhibiting NR4A1, SND-635 aims to disrupt these oncogenic pathways and induce apoptosis in cancer cells.
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