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sNinj1-NP
- Development stage
- Preclinical
- Lead developer
- Asahikawa Medical University
- Modality
- Peptides, Nanoparticles → Drug Delivery Systems
- Administration
- Intraperitoneal
01
Overview
sNinj1-NP is a sustained-release nanoparticle formulation of a soluble ninjurin-1 (sNinj1)-mimetic peptide encapsulated in poly(lactic-co-glycolic acid) (PLGA) microspheres. Developed by researchers at Asahikawa Medical University, sNinj1-NP mimics the cleaved extracellular domain of Ninjurin-1 (sNinj1) to exert anti-inflammatory and endothelial-protective effects. It competitively inhibits the homophilic adhesion and oligomerization of membrane-bound Ninjurin-1 (Ninj1), thereby suppressing macrophage activation, reducing the expression of pro-inflammatory cytokines (such as IL-6 and IL-1β), and preserving endothelial nitric oxide synthase (eNOS) expression. In preclinical models of cecum ligation puncture (CLP)-induced sepsis, sNinj1-NP administration significantly improved survival rates and attenuated sepsis-induced kidney dysfunction and acute kidney injury.
- Other names
- soluble ninjurin-1 nanoparticlessustained-release soluble ninjurin-1 nanoparticles
02
Targets
NINJ1 (Ninjurin-1)
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