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SNIPR001
- Development stage
- Phase 2
- Lead developer
- SNIPR Biome
- Modality
- CRISPR-Cas9 → CRISPR Systems → Programmable Nucleases → Gene Editing → Gene Therapies, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
- Administration
- Intralesional, Intravenous, Oral, Topical
01
Overview
**SNIPR001** is an investigational precision antimicrobial developed by SNIPR Biome. It is a cocktail of four engineered CRISPR-Cas-armed bacteriophages designed to selectively infect and eliminate *Escherichia coli* in the gastrointestinal tract while minimizing disruption of commensal microbiota. The oral program is in Phase 1b/2a development for prevention of fluoroquinolone-resistant *E. coli* bloodstream infections in patients with hematologic malignancies undergoing allogeneic hematopoietic stem-cell transplantation and receiving fluoroquinolone prophylaxis. A completed first-in-human Phase 1 study in healthy participants supported oral safety, tolerability, gastrointestinal restriction, and pharmacodynamic reduction of targeted *E. coli* colonization. ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/41785880/))
- Other names
- SNIPR 001SNIPR001SNIPR-001
02
Targets
bacterial dsDNA (Bacterial double-stranded DNA)
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