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SNK01 + pembrolizumab
- Development stage
- Phase 1
- Lead developer
- NKGen Biotech, Inc.
- Modality
- CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
SNK01 + pembrolizumab is a combination therapy consisting of pembrolizumab (a PD-1 inhibitor) and SNK01 (autologous ex-vivo expanded natural killer cells with enhanced cytotoxicity). This combination has shown improved efficacy compared to pembrolizumab monotherapy in advanced non-small cell lung cancer patients who failed prior frontline platinum-based therapy. The therapy works by combining the immune checkpoint inhibition mechanism of pembrolizumab with the enhanced cytotoxicity of SNK01 NK cells, creating a synergistic effect against cancer cells.
- Other names
- troculeucelautologous NK cell therapy
02
Targets
PDCD1 (Programmed cell death protein 1 receptor)
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