SNX-482

SNX-482 is a peptide toxin derived from the venom of the African tarantula *Hysterocrates gigas*. It functions as a potent and selective inhibitor of voltage-gated calcium channels, specifically the CaV2.3 subtype (R-type calcium channels), with an IC50 of 30 nM. Additionally, it exhibits potent inhibitory effects on A-type potassium currents, particularly Kv4.3 channels (IC50 < 3 nM), and to a lesser extent, Kv4.2 channels. Its mechanism of action involves binding to the voltage-sensing domains of these ion channels, thereby modulating their activation and gating kinetics. SNX-482 has been utilized as a research tool to investigate the roles of these specific ion channels in various physiological and pathological processes, including its antinociceptive properties observed in models of chronic neuropathic pain.