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SOCS6 siRNA
- Development stage
- Preclinical
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
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Overview
SOCS6 siRNA is a small interfering RNA designed to silence the expression of the Suppressor of Cytokine Signaling 6 (SOCS6) gene. SOCS6 is a member of the SOCS family that acts as a negative regulator of cytokine signaling and receptor tyrosine kinase pathways, primarily by promoting the ubiquitination and degradation of signaling proteins. In colorectal cancer (CRC), SOCS6 is identified as a tumor suppressor; its knockdown via siRNA has been shown to increase cell viability, colony formation, and migration in vitro. The siRNA is used to investigate the SOCS6-EPOR (Erythropoietin Receptor) axis, where SOCS6 normally regulates EPOR expression. This molecular tool is being explored for its potential in personalized CRC therapy and as a diagnostic marker.
- Other names
- Suppressor of cytokine signaling 6 siRNAsiSOCS6siSOCS-6siSOCS 6SOCS6-targeting siRNASOCS-6-targeting siRNASOCS 6-targeting siRNA
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