sodium (3β-hydroxy-(17r)-17-28-norurs-12(13)-en)-2-oxoethyl-phosphonate

sodium (3β-hydroxy-(17r)-17-28-norurs-12(13)-en)-2-oxoethyl-phosphonate is a semisynthetic pentacyclic triterpenoid derivative based on the ursolic acid scaffold. It features a methylphosphonate moiety attached to the C-17 position via a 2-oxoethyl linker, a modification specifically designed to improve the poor bioavailability and pharmacokinetic profile typically associated with natural triterpenoids. In preclinical evaluations using the B164A5 murine melanoma cell line, the compound demonstrated dose-dependent antiproliferative and anti-migratory activity. Preliminary safety and toxicological assessments, including the LDH test and HET-CAM assay, indicate that the derivative maintains a favorable safety profile without significant non-specific cytotoxicity or vascular irritation compared to its parent compound.

Other names

sodium ursolic acid phosphonate derivativeursolic acid C17-phosphonate sodium salt