Drug intelligence / Profile preview

sodium 3-beta-hydroxybutyrate

Development stage
Preclinical
Lead developer
Skejby Sygehus
Modality
Small Molecules
Administration
Intravenous, Oral
01

Overview

Sodium 3-beta-hydroxybutyrate (also known as sodium beta-hydroxybutyrate or sodium BHB) is the sodium salt form of beta-hydroxybutyrate, a naturally occurring ketone body produced by the liver during ketosis. It is widely used as a dietary supplement to support energy production, enhance cognitive function, and ease the transition into ketosis. Additionally, sodium 3-beta-hydroxybutyrate is utilized as an investigational agent and therapeutic adjunct in clinical research and for rare inborn errors of metabolism, such as multiple acyl-CoA dehydrogenase deficiency (MADD) and glycogen storage disease type III (GSD III), where fatty acid oxidation or glycogenolysis is impaired. It acts as an alternative energy substrate, particularly for the brain and heart, bypassing glucose metabolism pathways.

Other names
beta-hydroxybutyrate sodiumbeta-hydroxybutyrate sodium saltsodium 3-hydroxybutanoatesodium3-hydroxybutanoatesodium-3-hydroxybutanoatesodium 3-hydroxybutyratesodium3-hydroxybutyratesodium-3-hydroxybutyratesodium beta-hydroxybutanoatesodium beta-hydroxybutyratesodium BHB
02

Targets

FFAR3 (Free fatty acid receptor 3)HCAR2 (Hydroxycarboxylic acid receptor 2)HDAC1 (Histone Deacetylase 1)HDAC3 (Histone Deacetylase 3)HDAC4

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