Drug intelligence / Profile preview

sodium azulenesulfonate

Development stage
Phase 4
Lead developer
Nippon Shinyaku
Modality
Small Molecules
Administration
Oral, Topical
01

Overview

Sodium azulenesulfonate (also known as sodium gualenate) is a water-soluble derivative of azulene, a natural anti-inflammatory compound extracted from chamomile (*Matricaria chamomilla*). It is widely used as a mucosal protective and anti-inflammatory agent to treat gastrointestinal disorders, such as chronic gastritis, gastric ulcers, and duodenal ulcers, as well as localized inflammatory conditions of the mouth and throat (e.g., pharyngitis, tonsillitis, stomatitis). Sodium azulenesulfonate exerts its therapeutic effects by directly acting on inflamed mucosal tissues to inhibit histamine release from mast cells, reduce pepsin activity, and increase mucosal prostaglandin E2 synthesis, which promotes granulation tissue formation and epithelial cell regeneration.

Brand names
Asada-Ame AZ GargleAzulonAzunolAzunol STAzupromin
Other names
azulene sodium sulfonateazulene sulfonate sodiumazulenesulfonic acid sodiumgualenate de sodiumgualenato de sodiogualenato sodicogualenato sodidiconatrii gualenassodium 1,4-dimethyl-7-isopropylazulene-3-sulfonatesodium 3,8-dimethyl-5-propan-2-ylazulene-1-sulfonatesodium 5-isopropyl-3,8-dimethyl-1-azulene sulfonatesodium 7-isopropyl-1,4-dimethylazulene-3-sulfonatesodium gualenatesodium gualenate hydratesodium guaiazulene sulfonatesodium guaiazulene-3-sulfonatesodium guaiazulenesulfonate薁磺酸钠
02

Targets

COXOLR1 (Lectin-like oxidized LDL receptor-1)MRP (Multidrug resistance-associated protein family)TACR1 (Neurokinin‑1 Receptor)TACR2 (Neurokinin-2 Receptor)ABCB1 (P-glycoprotein)TRPV1 (Transient receptor potential cation channel subfamily V member 1)

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