Drug intelligence / Profile preview

sodium bicarbonate dentifrice

Development stage
Unknown
Lead developer
RepHresh Pro-B
Modality
Small Molecules
Administration
Topical
01

Overview

Sodium bicarbonate dentifrice refers to experimental toothpaste formulations developed by Church & Dwight Company, Inc., specifically those containing high concentrations (20% and 35%) of sodium bicarbonate (baking soda). These products are designed for the reduction of dental plaque and the treatment of gingivitis. Sodium bicarbonate functions as a mild abrasive that mechanically disrupts the dental plaque biofilm during brushing. Furthermore, it provides a buffering effect that creates an alkaline environment in the oral cavity, which can neutralize plaque acids, inhibit the growth of certain oral pathogens, and potentially reduce gingival inflammation and bleeding. These specific formulations were evaluated in a Phase 2 clinical trial (NCT03214406) to compare their long-term efficacy against a non-sodium bicarbonate control in adults.

Brand names
Arm & Hammer
Other names
baking soda toothpastesodium bicarbonate toothpastebaking soda dentifrice

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