Drug intelligence / Profile preview

sodium bituminosulfonate + salicylic acid

Development stage
Unknown
Lead developer
Ichthyol-Gesellschaft Cordes, Hermanni & Co.
Modality
Small Molecules
Administration
Topical
01

Overview

Aknichthol is a topical anti-acne medication developed by Ichthyol-Gesellschaft Cordes Hermanni & Co, specifically formulated for the treatment of various forms of acne, including acne vulgaris. It is a combination product containing light sodium bituminosulfonate (Ichthyol-Sodium, light) and salicylic acid. Sodium bituminosulfonate is a sulfonated shale oil derivative that exhibits anti-inflammatory, antimicrobial, and anti-seborrheic properties, which help to reduce the redness, bacterial load (particularly *Cutibacterium acnes*), and oiliness associated with acne lesions. Salicylic acid acts as a keratolytic agent, softening and promoting the exfoliation of the stratum corneum, which helps to unclog pores and prevent the formation of new comedones. The formulation is typically presented as a lotion that may also contain zinc oxide or titanium dioxide to provide a drying effect and cosmetic coverage of inflamed skin areas.

Brand names
Aknichthol
Other names
Ichthyol-Sodium + Salicylic acid
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)KLK5 (Kallikrein-related peptidase 5)PGHS-1 (Prostaglandin G/H Synthase 1)ALOX5 (Arachidonate 5-lipoxygenase)

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