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sodium chloride + Refresh Liquigel
- Development stage
- Unknown
- Lead developer
- Allergan
- Modality
- Small Molecules, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Non-biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Injectable Hydrogels → Hydrogel Systems → Drug Delivery Systems, Implantable Hydrogels → Hydrogel Systems → Drug Delivery Systems
- Administration
- Subconjunctival, Ophthalmic
01
Overview
The combination of sodium chloride (0.9% NaCl) and Refresh Liquigel (carboxymethylcellulose sodium 1%) represents a specific control/placebo regimen used in clinical research, notably in a Phase 1/2 trial led by Dr. Reza Dana at Massachusetts Eye and Ear. In this protocol, sodium chloride is administered as a one-time subconjunctival injection on the day of a corneal transplant, followed by a four-week course of topical Refresh Liquigel applied four times daily. This combination serves as a vehicle control to evaluate the safety and efficacy of anti-angiogenic treatments, such as bevacizumab, in preventing corneal graft failure in high-risk patients with corneal neovascularization. Sodium chloride acts as an isotonic vehicle for the injection, while Refresh Liquigel, manufactured by Allergan, is a lubricating eye gel containing carboxymethylcellulose sodium that supports ocular surface hydration and provides symptomatic relief.
- Other names
- 0.9% NaCl & Refresh Liquigel
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