Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
sodium chloride + Refresh Liquigel
- Development stage
- Unknown
- Lead developer
- Allergan
- Modality
- Implantable Hydrogels → Hydrogel Systems → Drug Delivery Systems, Small Molecules, Non-biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Injectable Hydrogels → Hydrogel Systems → Drug Delivery Systems
- Administration
- Subconjunctival, Ophthalmic
01
Overview
The combination of sodium chloride (0.9% NaCl) and Refresh Liquigel (carboxymethylcellulose sodium 1%) represents a specific control/placebo regimen used in clinical research, notably in a Phase 1/2 trial led by Dr. Reza Dana at Massachusetts Eye and Ear. In this protocol, sodium chloride is administered as a one-time subconjunctival injection on the day of a corneal transplant, followed by a four-week course of topical Refresh Liquigel applied four times daily. This combination serves as a vehicle control to evaluate the safety and efficacy of anti-angiogenic treatments, such as bevacizumab, in preventing corneal graft failure in high-risk patients with corneal neovascularization. Sodium chloride acts as an isotonic vehicle for the injection, while Refresh Liquigel, manufactured by Allergan, is a lubricating eye gel containing carboxymethylcellulose sodium that supports ocular surface hydration and provides symptomatic relief.
- Brand names
- Refresh Liquigel
- Other names
- 0.9% NaCl & Refresh Liquigel
Beyond the preview
Go deeper on sodium chloride + Refresh Liquigel.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on sodium chloride + Refresh Liquigel.