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Saline eyedrops are sterile ophthalmic solutions primarily composed of sodium chloride in purified water. They are available in various concentrations, typically 0.9% (isotonic) for eye irrigation and 5% (hypertonic) for the treatment of corneal edema. Isotonic saline works mechanically to wash out debris, allergens, or foreign bodies from the ocular surface, while hypertonic saline acts as an osmotic agent to draw excess fluid from the cornea. These solutions are non-proprietary, available over-the-counter, and frequently utilized as a placebo or control arm in clinical trials for other ophthalmic medications.
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