Drug intelligence / Profile preview

sodium chloride + sodium lactate + calcium chloride + potassium chloride + dextrose

Development stage
Approved
Lead developer
Pfizer
Modality
Small Molecules
Administration
Intravenous, Parenteral
01

Overview

Sodium chloride + sodium lactate + calcium chloride + potassium chloride + dextrose is a **multi-electrolyte intravenous crystalloid solution** used for parenteral replacement of extracellular fluid and electrolytes and as a source of water, electrolytes, and limited carbohydrate calories. It is marketed as **Lactated Ringer's and Dextrose** or **Dextrose in Lactated Ringers** and has been manufactured by companies including **Pfizer** and **ICU Medical**. Pharmacologically, it does not act through a single discrete molecular target; instead, sodium, potassium, calcium, chloride, lactate, and dextrose collectively restore intravascular and interstitial fluid composition, support acid-base balance through metabolism of lactate to bicarbonate, and provide modest caloric support through dextrose. It is administered as an **intravenous solution for injection/infusion** in adults and pediatric patients requiring fluid and electrolyte replacement or alkalinization.

Brand names
Lactated Ringer's and DextroseDextrose in Lactated Ringers
Other names
sodium chloride + sodium lactate + calcium chloride + potassium chloride + dextroselactated ringer's and dextrosedextrose in lactated ringerslactated ringer's and dextrose injectionlactated ringer's and dextrose 5% injectionpotassium chloride in lactated ringer's and dextrose injection

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