sodium chloride 0.3% in glucose 3.3%

Sodium chloride 0.3% in glucose 3.3% is a hypotonic intravenous crystalloid solution utilized as a maintenance fluid in the CRUSADERS trial (NCT05238506), led by University Hospital, Antwerp. This solution is a central component of a sodium chloride reduction strategy aimed at preventing fluid accumulation and electrolyte imbalances, such as hypernatremia and hyperchloremia, in critically ill adults in the intensive care unit (ICU). By providing a lower concentration of sodium and chloride compared to standard isotonic fluids like PlasmaLyte or 0.9% normal saline, and incorporating glucose to maintain plasma osmolarity, the strategy seeks to improve clinical outcomes, including the number of days patients remain alive and free of life support.

Other names

NaCl 0.3% in glucose 3.3%Reduced sodium chloride maintenance fluidCRUSADERS intervention fluidHypotonic saline with glucose