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sodium cholate + aminophylline
- Development stage
- Phase 4
- Lead developer
- Union Hospital of Huazhong University of Science and Technology
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Compound Sodium Cholate and Aminophylline Tablets is an oral combination drug product containing sodium cholate, a bile salt, and aminophylline, a methylxanthine bronchodilator. Aminophylline is a 2:1 complex of theophylline and ethylenediamine that acts as a non-selective phosphodiesterase (PDE) inhibitor and adenosine receptor antagonist, resulting in bronchodilation and anti-inflammatory effects. Sodium cholate is included as a bile acid component that may serve as a mucolytic or absorption-enhancing agent. This combination is used in the Chinese clinical setting for respiratory conditions such as bronchial asthma and chronic bronchitis, and it is currently being investigated in a Phase 4 clinical trial for the treatment of mild to moderate acute exacerbations of chronic obstructive pulmonary disease (AECOPD).
- Other names
- Compound Sodium Cholate and Aminophylline TabletsCompound Sodium Chlorate and Aminophylline Tabletssodium chlolate + aminophylline
02
Targets
PDE (Phosphodiesterase family)ADOR (Adenosine receptors)HDAC2 (Histone deacetylase 2)
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