Drug intelligence / Profile preview

sodium fluoride + silica + carbopol

Development stage
Unknown
Modality
Small Molecules, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
Administration
Dental, Topical
01

Overview

Sodium fluoride + silica + carbopol is a combination commonly found in toothpaste and dental gel formulations. Sodium fluoride acts as an anti-caries agent, helping to prevent and control dental caries by promoting remineralization of tooth enamel and inhibiting demineralization[3][2]. Silica serves as an abrasive to aid in the mechanical removal of dental plaque and surface stains during brushing. Carbopol (a brand name for a family of synthetic high molecular weight polymers of acrylic acid) functions as a thickening or gelling agent, improving the texture, stability, and retention time of the formulation on teeth[4][5]. The combination enhances both cleaning efficacy (via silica) and anti-cavity protection (via sodium fluoride), while Carbopol can potentiate the protective effect by increasing retention of active ingredients on enamel surfaces[5]. These formulations are primarily indicated for daily oral hygiene to prevent tooth decay.

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