Sodium fluoride mouthwash 250 ppm

This drug refers to the negative control formulation used in clinical trials sponsored by Colgate-Palmolive for the treatment of gingivitis and dental plaque. It is a sodium fluoride-based mouthwash containing 250 ppm of fluoride. In the context of these studies, it serves as a standard-of-care or non-antimicrobial comparator to evaluate the efficacy of experimental mouthrinses, such as the amine fluoride/zinc lactate system (meridol). Sodium fluoride primarily functions as an anti-caries agent by promoting the remineralization of tooth enamel and inhibiting demineralization, but it lacks the specific antimicrobial properties targeted for significant gingivitis reduction.

Other names

negative controlSodium fluoride mouthwash