Drug intelligence / Profile preview

sodium hyaluronate

Development stage
Phase 4
Modality
Recombinant Proteins and Enzymes
Administration
Intraarticular, Ophthalmic, Topical
01

Overview

Sodium hyaluronate is the sodium salt of hyaluronic acid—a naturally occurring glycosaminoglycan found in connective tissues. It acts as a lubricant and shock absorber in joints and is used primarily to relieve pain from osteoarthritis of the knee when other treatments have failed. Sodium hyaluronate is also used as a surgical aid in ophthalmic procedures to protect eye tissues and as a topical agent for wound healing. Its mechanism of action involves forming a viscoelastic solution that provides mechanical protection for tissues by absorbing stress and serving as a protective buffer. It may also facilitate tissue repair by transporting growth factors to sites of injury[1][2][3][4][5][8].

Brand names
DurolaneEuflexxaGel-OneGelsyn-3Gelsyn3Gelsyn 3GenVisc 850GenVisc850GenVisc-850HyalganSupartzTriluronTriVisc
Other names
hyaluronate sodium
02

Targets

TNFAIP6LYVE1 (Lymphatic vessel endothelial hyaluronic acid receptor 1)VCAN (Versican / VCAN)ACAN (Aggrecan core protein)CD44 (CD44 antigen)ICAM1 (Intercellular Adhesion Molecule 1)RHAMM (Hyaluronan-mediated motility receptor)

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