sodium hyaluronate + sodium bicarbonate + sodium fluoride

This experimental toothpaste formulation, developed by GSK, is a topical oral care product designed for the treatment of mild-to-moderate gingivitis. It contains a combination of 0.2% high molecular weight (HMW) sodium hyaluronate, 67% w/w sodium bicarbonate, and 0.221% w/w sodium fluoride. The mechanism of action involves sodium bicarbonate facilitating mechanical plaque removal, while sodium hyaluronate is intended to inhibit plaque accumulation and promote gingival healing by potentially reducing cell proliferation in gingival epithelial cells. Sodium fluoride provides standard anticaries protection through enamel remineralization. Although a Phase II proof-of-principle clinical trial (NCT04737538) demonstrated significant anti-gingivitis efficacy, the formulation did not show additional clinical benefits over a toothpaste containing only sodium bicarbonate and sodium fluoride.

Other names

Experimental DentifriceGSK experimental toothpastesodium hyaluronate-GlaxoSmithKline-gingivitis