Drug intelligence / Profile preview

sodium iodide I-124

Development stage
Unknown
Lead developer
Sant’Orsola-Malpighi University Hospital
Modality
Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration
Oral
01

Overview

Sodium iodide I-124 is a positron-emitting radiopharmaceutical used as a diagnostic imaging agent for PET/CT. It contains the radioisotope iodine-124, which is actively transported into thyroid cells via the sodium iodide symporter (NIS). Its primary clinical application is for pre-therapeutic individualized lesion dosimetry in patients with differentiated thyroid carcinoma (DTC), particularly those with lung or bone metastases, to optimize subsequent treatment with iodine-131. By providing high-resolution PET images, it allows for more accurate quantification of iodine uptake and residence time compared to traditional planar imaging or SPECT. It is currently being evaluated in clinical trials as an investigational tool for personalized dosimetry.

Other names
sodium iodide (124I)iodine-124 sodium iodideiodine124 sodium iodideiodine 124 sodium iodide
02

Targets

NIS (Human sodium iodide symporter)

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