sodium lauryl sulfate

Sodium lauryl sulfate (SLS) is an anionic surfactant and detergent widely used in clinical research as a positive control for skin irritation. In studies sponsored by SerenaGroup, Inc., such as the Human Repeat Insult Patch Test (HRIPT) for the SILURCLOUD Fibrous Collagen Matrix, SLS is utilized to induce a predictable inflammatory response in healthy volunteers. This application allows for the assessment of the experimental material's relative safety and the validation of the test's sensitivity. SLS acts by solubilizing the lipids of the stratum corneum and denaturing epidermal proteins like keratin, which compromises the skin's barrier function and leads to localized irritation. It is a standard reference material in the assessment of skin sensitization and irritation potential for new medical devices and topical formulations.

Brand names

Kolliphor SLSKolliphor SLS Fine

Other names

Sodium dodecyl sulfateDodecyl sodium sulfateLauryl sodium sulfate