sodium lauryl sulfate + cocamidopropyl betaine + sodium fluoride

A combination ingredient blend typically found in toothpaste and other oral care products. **Sodium lauryl sulfate** is an anionic surfactant that acts as a foaming agent and cleanser, **cocamidopropyl betaine** is a mild amphoteric surfactant used to boost foam and reduce irritation, and **sodium fluoride** is an anticaries agent that helps protect enamel and reduce dental caries. In dental products, this combination works to clean the oral cavity, facilitate distribution of agents, enhance foaming, and deliver fluoride for cavity prevention. This combination is not available as a uniquely branded pharmaceutical but is widely used in over-the-counter dentifrice formulations. Mechanistically: - Sodium lauryl sulfate and cocamidopropyl betaine disrupt and remove oral debris and bacterial plaque by breaking surface tension and providing foaming action. - Sodium fluoride is a well-established anti-caries agent that strengthens enamel through remineralization and inhibits demineralization by acting on the hydroxyapatite structure in teeth[1][6][7][9].