sodium monofluorophosphate + arginine toothpaste

This fluoride-containing toothpaste, developed by Colgate-Palmolive, is a combination product designed for the prevention of dental cavities. It features a unique formulation of 1000 ppm sodium monofluorophosphate (MFP) and 1.5% arginine in a calcium carbonate base (PCC/RNCC). The fluoride component works by integrating into the tooth enamel to form fluorapatite, which is more resistant to acid-induced demineralization and promotes the remineralization of early carious lesions. The arginine component acts as a substrate for arginolytic bacteria within the oral biofilm; these bacteria metabolize arginine into ammonia, which raises the local pH and neutralizes the organic acids produced by sugar-fermenting bacteria. This dual mechanism addresses both the mineral balance of the tooth and the metabolic activity of the plaque biofilm to prevent cavity formation.

Brand names

Colgate Maximum Cavity Protection plus Sugar Acid Neutralizer

Other names

Colgate Fluoride Toothpaste with Arginine1000 ppm MFP and 1.5% arginine toothpaste