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Drug intelligence / Profile preview
sodium monofluorophosphate 0.76% toothpaste
- Development stage
- Unknown
- Lead developer
- Colgate-Palmolive
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
This is a control toothpaste formulation containing 0.76% sodium monofluorophosphate (SMFP), developed by GSK for use as a negative control in clinical trials evaluating treatments for dentinal hypersensitivity. Sodium monofluorophosphate is a source of fluoride used primarily for caries prevention; in the context of sensitivity trials, it serves as a standard non-desensitizing fluoride control to compare against active desensitizing agents like stannous fluoride or potassium nitrate. It works by releasing fluoride ions to promote remineralization of tooth enamel but lacks the specific tubule-occluding or nerve-desensitizing properties of the test agents.
- Other names
- 0.76% sodium monofluorophosphate toothpasteSMFP toothpaste
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