sodium monofluorophosphate toothpaste

A fluoride-containing dentifrice developed and marketed by GSK, most notably under the Sensodyne brand for the management of dentin hypersensitivity. The formulation typically contains sodium monofluorophosphate (SMFP) as the active ingredient, often at a concentration of 1000 ppm fluoride. Its primary therapeutic role is the prevention of dental caries and the promotion of enamel remineralization; fluoride ions incorporate into the tooth structure to form fluorapatite, which is more resistant to acid-induced demineralization than naturally occurring hydroxyapatite. In clinical trials for dentin sensitivity, this toothpaste is frequently utilized as a standardized background treatment or a control arm to isolate the efficacy of adjunct desensitizing agents, such as dipotassium oxalate or potassium nitrate, which may be delivered through experimental oral rinses or specialized toothpaste variants.

Brand names

SensodyneAquafreshMacleans

Other names

fluoride toothpasteSMFP toothpastestandard fluoride toothpaste