Drug intelligence / Profile preview

sodium pertechnetate tc-99m

Development stage
Approved
Lead developer
V.G. Khlopin Radium Institute
Modality
Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration
Intravenous
01

Overview

Sodium pertechnetate (99mTc) is a diagnostic radiopharmaceutical developed and produced by the Khlopin Radium Institute. It contains the technetium-99m radionuclide, which is a metastable nuclear isomer that decays by emitting gamma radiation with a principal energy of 140 keV, making it ideal for scintigraphy and Single Photon Emission Computed Tomography (SPECT) imaging. The pertechnetate ion (TcO4-) is a monovalent anion that shares similar biological transport mechanisms with iodide, specifically being concentrated in the thyroid gland, salivary glands, and gastric mucosa via the sodium-iodide symporter (NIS). It is used clinically for the diagnostic imaging of various organs, including the thyroid, brain, and salivary glands, and for the detection of ectopic gastric mucosa (Meckel's diverticulum). Additionally, it serves as the primary precursor and starting material for the preparation of a wide range of other technetium-99m labeled radiopharmaceuticals through the use of specialized reaction kits.

Brand names
TechneLite
Other names
Натрия пертехнетат99mTc Sodium PertechnetateSodium Pertechnetate (99mTc)Technetium-99m pertechnetateTechnetium99m pertechnetateTechnetium 99m pertechnetateSodium pertechnetate [99mTc] injection
02

Targets

NIS (Human sodium iodide symporter)

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