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Sodium phosphate monobasic monohydrate is an inorganic small molecule that serves as a source of phosphorus and an osmotic agent. It is widely utilized in pharmaceutical formulations, most notably as an active ingredient in osmotic laxatives for bowel cleansing prior to colonoscopy and as an intravenous electrolyte replenisher to treat or prevent hypophosphatemia. In the gastrointestinal tract, it increases osmotic pressure, drawing water into the intestinal lumen to promote evacuation. Systemically, it provides inorganic phosphate essential for ATP synthesis, bone mineralization, and maintaining acid-base balance via the phosphate buffer system. It is typically co-formulated with sodium phosphate dibasic in commercial products.
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