sodium stibogluconate

Sodium stibogluconate is an injectable pentavalent antimonial compound used primarily for the treatment of leishmaniasis (cutaneous, visceral, and mucosal forms), a parasitic disease transmitted by sand-fly bites. It is classified as an antiprotozoal agent and has been in medical use since the 1940s. The drug is on the World Health Organization's List of Essential Medicines. Its mechanism of action is not fully understood but appears to involve inhibition of macromolecular synthesis in Leishmania parasites through reduction in available ATP and GTP—likely secondary to inhibition of glycolysis and the citric acid cycle. Sodium stibogluconate may also have orphan designation for acute myeloid leukemia (AML). It is administered by intravenous or intramuscular injection[1][2][3][4][5][6].

Brand names

PentostamSolustibosanSolyusurminMyostibinTriostam

Other names

antimony sodium gluconateantimony gluconic acidantimony sodium gluconatessodium gluconates antimonystibatinstibogluconate sodium