sodium tanshinone IIA sulfonate + sildenafil citrate

Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of the active compound tanshinone IIA from *Salvia miltiorrhiza* (Danshen), a traditional Chinese medicinal herb. STS exhibits multiple pharmacological activities including anti-oxidant, anti-inflammatory, and anti-apoptotic effects. It has been approved in China for cardiovascular diseases and is being investigated for pulmonary hypertension (PH), where it may improve exercise capacity and reduce symptoms either alone or in combination with other agents[1][4]. Sildenafil citrate is a phosphodiesterase-5 (PDE5) inhibitor approved for erectile dysfunction and pulmonary arterial hypertension (PAH). It works by inhibiting PDE5 to increase cyclic GMP levels, leading to vasodilation in the pulmonary vasculature[2]. The combination of STS with sildenafil has shown promising results in improving outcomes for patients with PH[1][8].

Other names

STS + sildenafilsodium tanshinone IIA sulfonate and sildenafil citrate