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sodium trisulfide
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Intraperitoneal
01
Overview
Sodium trisulfide (Na2S3) is an inorganic polysulfide and sulfane sulfur donor that acts as a fast-releasing hydrogen sulfide (H2S) and hydrogen polysulfide (H2Sn) donor. It is widely utilized as a research tool to investigate the physiological and pharmacological roles of reactive sulfur species (RSS) and supersulfides in cellular signaling and cytoprotection. Preclinical studies have demonstrated that sodium trisulfide exerts protective effects against hepatic ischemia-reperfusion injury (IRI) by mitigating oxidative stress, restoring mitochondrial function, and maintaining the expression of key enzymes in the sulfide oxidation pathway, such as sulfide-quinone oxidoreductase (SQOR). Additionally, it has shown neuroprotective properties in models of dopaminergic neurodegeneration and intracerebral hemorrhage.
- Other names
- disodium trisulfideNa2S3Na-2S3Na 2S3sodium sesquisulfidesodium sulfide (Na2(S3))sodium trisulfide anhydrous
02
Targets
TRPA1 (Transient receptor potential cation channel subfamily A member 1)
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