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sodium valproate
- Development stage
- Unknown
- Lead developer
- Desitin Arzneimittel
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Sodium valproate is a widely used anticonvulsant and mood-stabilizing medication primarily indicated for the treatment of various forms of epilepsy and bipolar disorder. It functions through a multi-modal mechanism of action, including the enhancement of gamma-aminobutyric acid (GABA) levels by inhibiting GABA transaminase, the blockade of voltage-gated sodium channels, and the inhibition of T-type calcium channels. Additionally, it acts as a non-selective inhibitor of histone deacetylases (HDACs), contributing to its neuroprotective and mood-stabilizing effects. TwinPharma markets specific formulations of sodium valproate, including modified-release (enteric-coated) tablets and an oral solution, typically under license or distribution agreements in the European market.
- Brand names
- Natriumvalproaat msr tablettenNatriumvalproaat drank
- Other names
- natriumvalproaatvalproate sodiumsodium 2-propylpentanoatesodium2-propylpentanoatesodium-2-propylpentanoate
02
Targets
HDAC (HDAC family)NaV (Voltage-gated sodium channels)ABAT (4-aminobutyrate aminotransferase)CaV3 (Caveolin-3)
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