Drug intelligence / Profile preview

solidago virga-aurea extract

Development stage
Preclinical
Lead developer
Hallym University
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral, Topical
01

Overview

Solidago virga-aurea extract is a botanical extract derived from the flowering aerial parts of *Solidago virgaurea* (European goldenrod or woundwort), a perennial herb belonging to the Asteraceae family. Traditionally utilized for its diuretic, anti-inflammatory, and antiseptic properties, the extract has been investigated for its potential therapeutic applications in oncology, metabolic disorders, and dermatology. In preclinical studies, the extract has demonstrated the ability to induce apoptosis in breast cancer cells by upregulating the pro-apoptotic protein Bim via a FOXO3a-mediated pathway. Additionally, it has shown anti-adipogenic and anti-obesity effects in animal models, as well as antimicrobial activity against pathogens such as *Candida albicans*.

Other names
European goldenrod extractSolidago virgaurea extractwoundwort extract
02

Targets

PTPN1 (Protein tyrosine phosphatase 1B)Sucrase-Isomaltase

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